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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFdecreases response to substanceEXP 6480464CTDTNF protein results in decreased susceptibility to ParaquatPMID:1850207
TNFincreases expressionEXP 6480464CTDParaquat results in increased expression of TNF mRNA; Paraquat results in increased expression of TNF proteinPMID:18836921 PMID:22493042 PMID:22736252 PMID:28363843 PMID:29454966 PMID:36108500
TNFincreases secretionEXP 6480464CTDParaquat results in increased secretion of TNF proteinPMID:30088170
TNFmultiple interactionsEXP 6480464CTD[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Paraquat results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of TNF protein]; NFE2L2 protein inhibits the reaction [Paraquat results in increased expression of TNF protein]; Paraquat results in increased expression of and results in increased secretion of TNF protein; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Paraquat results in increased expression of TNF protein]; TLR9 protein promotes the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; TLR9 protein promotes the reaction [Paraquat results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Paraquat results in increased expression of CAT protein]; TNF protein promotes the reaction [Paraquat results in increased expression of MT1A protein]; TNF protein promotes the reaction [Paraquat results in increased expression of SOD1 protein]; TNF protein promotes the reaction [Paraquat results in increased expression of SOD2 protein]; TNFAIP6 protein inhibits the reaction [Paraquat results in increased expression of TNF mRNA]PMID:22493042 PMID:22736252 PMID:24912639 PMID:26313688 PMID:27890776 PMID:28363843 PMID:28474156 PMID:30088170 PMID:7532385 PMID:8317554
TNFaffects expressionISOTnf (Rattus norvegicus)6480464CTDParaquat affects the expression of TNF proteinPMID:25215149
TNFdecreases expressionISOTnf (Mus musculus)6480464CTDParaquat results in decreased expression of TNF mRNAPMID:28012437
TNFdecreases expressionISOTnf (Rattus norvegicus)6480464CTDParaquat results in decreased expression of TNF mRNAPMID:18198484
TNFincreases expressionISOTnf (Mus musculus)6480464CTDParaquat results in increased expression of TNF; Paraquat results in increased expression of TNF mRNA; Paraquat results in increased expression of TNF proteinPMID:16324872 PMID:16919916 PMID:21801858 PMID:23510834 PMID:23603004 PMID:23969119 PMID:24893116 PMID:25304964 PMID:25461551 PMID:26099602 PMID:26988026 PMID:27014807 PMID:27890776 PMID:28090784 PMID:28131803 PMID:28363843 PMID:28480221 PMID:28600744 PMID:29441825 PMID:30562684 PMID:30571954 PMID:30584891 PMID:33737140 PMID:34811946 PMID:36031164 PMID:36108500 PMID:36462643
TNFincreases expressionISOTnf (Rattus norvegicus)6480464CTDParaquat results in increased expression of TNF mRNA; Paraquat results in increased expression of TNF proteinPMID:12504350 PMID:15135310 PMID:16824337 PMID:19497220 PMID:20498031 PMID:21040696 PMID:21921364 PMID:23159886 PMID:24521700 PMID:24812154 PMID:24912633 PMID:24912639 PMID:25891457 PMID:26221080 PMID:26313688 PMID:26722498 PMID:28123623 PMID:28474156 PMID:28696894 PMID:28921394 PMID:30088170 PMID:30967525 PMID:32020686 PMID:32060784 PMID:35707280 PMID:36394833
TNFincreases secretionISOTnf (Mus musculus)6480464CTDParaquat results in increased secretion of TNF proteinPMID:29441825 PMID:34863858 PMID:37028639
TNFincreases secretionISOTnf (Rattus norvegicus)6480464CTDParaquat results in increased secretion of TNF proteinPMID:24963491
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; [Cyclophosphamide co-treated with Methylprednisolone] inhibits the reaction [Paraquat results in increased expression of TNF protein]; [Maneb co-treated with Paraquat] results in increased expression of TNF mRNA; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of TNF protein]; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Cyclophosphamide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TNF protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; HSPD1 protein promotes the reaction [Paraquat results in increased expression of TNF mRNA]; IL17A protein promotes the reaction [Paraquat results in increased expression of TNF protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of TNF mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of TNF protein]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Paraquat results in increased expression of and results in increased secretion of TNF protein; Phosphorothioate Oligonucleotides inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; Phosphorothioate Oligonucleotides inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; resolvin D1 analog inhibits the reaction [Paraquat results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Paraquat results in increased expression of TNF protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; sodium boranocarbonate inhibits the reaction [Paraquat results in increased expression of TNF protein]; ST2825 inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; ST2825 inhibits the reaction [Paraquat results in increased expression of TNF protein]; T0901317 inhibits the reaction [Paraquat results in increased expression of TNF protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; TLR4 gene mutant form inhibits the reaction [Paraquat results in increased expression of TNF protein]; tricarbonylchloro(glycinato)ruthenium(II) inhibits the reaction [Paraquat results in increased expression of TNF protein]PMID:16919916 PMID:21801858 PMID:23510834 PMID:23603004 PMID:23963992 PMID:23969119 PMID:24893116 PMID:25461551 PMID:26099602 PMID:27890776 PMID:28090784 PMID:28131803 PMID:28202386 PMID:28363843 PMID:28480221 PMID:28600744 PMID:29568078 PMID:30562684 PMID:30571954 PMID:30584891 PMID:30797899 PMID:31299241 PMID:32169474 PMID:32375810 PMID:33737140 PMID:34052309 PMID:34811946 PMID:36031164 PMID:37028639
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Paraquat results in increased secretion of TNF protein]; [Mifepristone co-treated with Paraquat] results in increased expression of TNF protein; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; [pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; allyl sulfide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Ambroxol affects the reaction [Paraquat results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [Paraquat results in increased expression of TNF protein]; embelin inhibits the reaction [Paraquat results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased expression of TNF protein]; ginkgolide C inhibits the reaction [Paraquat results in increased expression of TNF protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of TNF protein]; Oxygen inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Paraquat promotes the reaction [Zinc results in increased expression of TNF protein]; Paraquat results in increased expression of and results in increased secretion of TNF protein; pirfenidone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Xuebijing inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Zinc promotes the reaction [Paraquat results in increased expression of TNF protein]PMID:16824337 PMID:21040696 PMID:21921364 PMID:23159886 PMID:24812154 PMID:24963491 PMID:25215149 PMID:25891457 PMID:26221080 PMID:26722498 PMID:28123623 PMID:28474156 PMID:28696894 PMID:28921394 PMID:30088170 PMID:32020686 PMID:32060784 PMID:35707280
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