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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox12
Name: arachidonate 12-lipoxygenase, 12S type
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox12decreases expressionEXP 6480464CTDCarmustine results in decreased expression of ALOX12 mRNAPMID:16005536
Alox12affects response to substanceISOAlox12 (Mus musculus)6480464CTDALOX12 protein affects the susceptibility to CarmustinePMID:19373248
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