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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735684
Species: Mus musculus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31, member 1
Acc ID: CHEBI:33364
Term: platinum
Definition: A nickel group element atom that has formula Pt.
Chemical ID: MESH:D010984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1affects response to substanceISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 affects the susceptibility to PlatinumPMID:21570711
Slc31a1increases uptakeISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein results in increased uptake of PlatinumPMID:22491798
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTD[Bortezomib results in decreased degradation of SLC31A1 protein] which results in increased uptake of Platinum; Trientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]PMID:22491798 PMID:24209693
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