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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736025
Species: Homo sapiens
RGD Object: Gene
Symbol: LDHA
Name: lactate dehydrogenase A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LDHAaffects expressionEXP 6480464CTDbisphenol A affects the expression of LDHA mRNAPMID:30903817
LDHAdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LDHA mRNA; bisphenol A results in decreased expression of LDHA proteinPMID:29275510 PMID:33024228 PMID:33670352
LDHAincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LDHA mRNA; bisphenol A results in increased expression of LDHA proteinPMID:34186270 PMID:37080528
LDHAmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole] results in decreased expression of LDHA mRNA; bisphenol A promotes the reaction [LDHA protein binds to ESR1 protein]PMID:37080528
LDHAaffects expressionISOLdha (Rattus norvegicus)6480464CTDbisphenol A affects the expression of LDHA mRNAPMID:30903817
LDHAdecreases expressionISOLdha (Mus musculus)6480464CTDbisphenol A results in decreased expression of LDHA mRNA; bisphenol A results in decreased expression of LDHA proteinPMID:24909818 PMID:35999755
LDHAdecreases expressionISOLdha (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of LDHA mRNAPMID:30816183 PMID:32528016
LDHAincreases activityISOLdha (Mus musculus)6480464CTDbisphenol A results in increased activity of LDHA proteinPMID:36858637
LDHAincreases expressionISOLdha (Mus musculus)6480464CTDbisphenol A results in increased expression of LDHA mRNAPMID:33221593
LDHAincreases expressionISOLdha (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of LDHA mRNA; bisphenol A results in increased expression of LDHA proteinPMID:12075121 PMID:25181051 PMID:32145629
LDHAmultiple interactionsISOLdha (Mus musculus)6480464CTDVDAC1 promotes the reaction [bisphenol A results in increased activity of LDHA protein]PMID:36858637
LDHAmultiple interactionsISOLdha (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of LDHA mRNAPMID:36041667
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