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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1affects expressionISOHmox1 (Rattus norvegicus)6480464CTDpirinixic acid affects the expression of HMOX1 proteinPMID:16863991
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDpirinixic acid results in decreased expression of HMOX1 mRNAPMID:19162173
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDpirinixic acid results in increased expression of HMOX1 mRNA; pirinixic acid results in increased expression of HMOX1 proteinPMID:18445702 PMID:25690736
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDpirinixic acid results in increased expression of HMOX1 mRNAPMID:15890375
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDpirinixic acid promotes the reaction [PPARA protein binds to HMOX1 promoter]PMID:20709802
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [pirinixic acid co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with pirinixic acid] results in increased expression of HMOX1 mRNAPMID:20368269
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