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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAaffects expressionEXP 6480464CTDArsenic Trioxide affects the expression of RELA proteinPMID:29274627
RELAaffects localizationEXP 6480464CTDArsenic Trioxide affects the localization of RELA proteinPMID:15547942 PMID:25972196 PMID:28115242 PMID:34303041
RELAdecreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of RELA proteinPMID:16105982 PMID:16174796 PMID:20471514 PMID:20534739
RELAdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of RELA mRNA; Arsenic Trioxide results in decreased expression of RELA protein; Arsenic Trioxide results in decreased expression of RELA protein modified formPMID:18349030 PMID:20435036 PMID:21078540 PMID:22949821 PMID:25196641 PMID:25436934 PMID:26110921 PMID:26160715 PMID:30093655 PMID:33634982
RELAdecreases phosphorylationEXP 6480464CTDArsenic Trioxide results in decreased phosphorylation of RELA proteinPMID:30612216
RELAdecreases response to substanceEXP 6480464CTDRELA protein results in decreased susceptibility to Arsenic TrioxidePMID:16174796
RELAincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of RELA proteinPMID:27561292 PMID:29396848 PMID:31307525
RELAincreases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of RELA proteinPMID:31734849 PMID:32305283
RELAmultiple interactionsEXP 6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RELA protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RELA protein]; 4-amino-1,8-naphthalimide inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; [[Sulindac co-treated with Arsenic Trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; [Arsenic Trioxide binds to PIN1 protein] affects the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; [Arsenic Trioxide co-treated with CSF2] results in decreased activity of RELA protein; [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; [Arsenic Trioxide co-treated with Plant Extracts] results in decreased expression of RELA protein; [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased activity of and results in increased localization of RELA protein; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of RELA mRNA; [Bortezomib co-treated with Arsenic Trioxide] results in decreased activity of RELA protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; allicin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; Arsenic Trioxide inhibits the reaction [EZH2 protein binds to RELA protein]; Arsenic Trioxide inhibits the reaction [RELA protein binds to NFKB1 protein]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Arsenic Trioxide promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of RELA mRNA]; Arsenic Trioxide promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of RELA protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of RELA protein]; Arsenic Trioxide results in decreased expression of and affects the localization of RELA protein; Arsenic Trioxide results in decreased phosphorylation of and affects the localization of RELA protein; Genistein promotes the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; JAK1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased phosphorylation of and affects the localization of RELA protein]; PIN1 protein affects the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased activity of RELA protein]; RELA protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 protein]]; RELA protein inhibits the reaction [Arsenic Trioxide results in decreased expression of CXCR4 protein]; RELA protein inhibits the reaction [Arsenic Trioxide results in decreased expression of ITGAX protein]; STAT3 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; tetraarsenic tetrasulfide promotes the reaction [Arsenic Trioxide results in decreased expression of RELA mRNA]; tetraarsenic tetrasulfide promotes the reaction [Arsenic Trioxide results in decreased expression of RELA protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of RELA protein]PMID:15314284 PMID:16174796 PMID:18575716 PMID:20471514 PMID:20534739 PMID:20889596 PMID:21078540 PMID:22384180 PMID:24680928 PMID:25047463 PMID:25972196 PMID:26110921 PMID:26160715 PMID:27561292 PMID:28115242 PMID:30093655 PMID:30333888 PMID:30612216 PMID:31307525 PMID:32305283 PMID:32645343 PMID:33634982
RELAaffects localizationISORela (Rattus norvegicus)6480464CTDArsenic Trioxide affects the localization of RELA proteinPMID:27664319 PMID:34037972
RELAincreases expressionISORela (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of RELA mRNAPMID:15073043
RELAincreases expressionISORela (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of RELA mRNA; Arsenic Trioxide results in increased expression of RELA proteinPMID:29130132 PMID:30368975 PMID:31258454 PMID:32920515 PMID:33173984
RELAincreases phosphorylationISORela (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of RELA proteinPMID:22488045 PMID:35317438
RELAincreases phosphorylationISORela (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased phosphorylation of RELA proteinPMID:31734849
RELAmultiple interactionsISORela (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RELA protein]; 18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RELA protein]; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of RELA protein; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RELA protein]PMID:21078540 PMID:22488045 PMID:34333357 PMID:35317438
RELAmultiple interactionsISORela (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; Phloretin inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]PMID:27664319 PMID:29130132 PMID:30368975 PMID:32920515 PMID:33173984 PMID:34037972
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