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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases expressionEXP 6480464CTDarsenite results in decreased expression of AKT1 mRNAPMID:18585952 PMID:31935557
AKT1increases activityEXP 6480464CTDarsenite results in increased activity of AKT1 proteinPMID:22040890
AKT1increases methylationEXP 6480464CTDarsenite results in increased methylation of AKT1 promoterPMID:23974009
AKT1increases phosphorylationEXP 6480464CTDarsenite results in increased phosphorylation of AKT1 proteinPMID:12640124 PMID:23469214 PMID:24024143
AKT1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein; SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; XPA protein affects the reaction [arsenite results in decreased expression of AKT1 mRNA]PMID:11788791 PMID:14971644 PMID:18585952 PMID:22040890 PMID:24024143
AKT1decreases expressionISOAkt1 (Mus musculus)6480464CTDarsenite results in decreased expression of AKT1 proteinPMID:15276423
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDarsenite results in decreased phosphorylation of AKT1 proteinPMID:17520061
AKT1increases expressionISOAkt1 (Mus musculus)6480464CTDarsenite results in increased expression of AKT1 mRNAPMID:18191166
AKT1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDarsenite results in increased phosphorylation of AKT1 proteinPMID:20377179
AKT1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDarsenite results in increased phosphorylation of AKT1 proteinPMID:20835880 PMID:23396362
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDarsenite results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Selenium inhibits the reaction [arsenite results in decreased expression of and results in decreased phosphorylation of AKT1 protein]PMID:20377179 PMID:29324385
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTDAKT1 protein modified form inhibits the reaction [arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; AKT1 protein modified form inhibits the reaction [arsenite results in increased expression of and results in increased phosphorylation of TRP53 protein]; AKT1 protein modified form inhibits the reaction [arsenite results in increased expression of CDKN1A protein]; AKT1 protein modified form inhibits the reaction [arsenite results in increased phosphorylation of RPS6 protein]; arsenite inhibits the reaction [INS1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of AKT1 protein]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of AKT1 protein]]; PIK3R1 gene mutant form inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]PMID:17520061 PMID:20835880 PMID:23396362
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