GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HMOX1 | increases expression | EXP | | 6480464 | CTD | Ascorbic Acid results in increased expression of HMOX1 mRNA | PMID:33248029 PMID:8743975 | HMOX1 | multiple interactions | EXP | | 6480464 | CTD | [Buthionine Sulfoximine co-treated with Ascorbic Acid] promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]; Ascorbic Acid promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA] | PMID:10942521 PMID:19683516 PMID:21199573 PMID:22053912 PMID:28285367 PMID:31610155 PMID:32525552 | HMOX1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Ascorbic Acid results in increased expression of HMOX1 protein | PMID:16171798 | HMOX1 | increases expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | Ascorbic Acid results in increased expression of HMOX1 mRNA; Ascorbic Acid results in increased expression of HMOX1 protein | PMID:22008531 PMID:23022510 | HMOX1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Ascorbic Acid inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Nelfinavir results in increased expression of HMOX1]; Ascorbic Acid promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA] | PMID:15577407 PMID:16517059 PMID:33475796 | HMOX1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 protein]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of HMOX1 protein]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; Methamphetamine promotes the reaction [Ascorbic Acid results in increased expression of HMOX1 mRNA]; Methamphetamine promotes the reaction [Ascorbic Acid results in increased expression of HMOX1 protein]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Ascorbic Acid results in increased expression of HMOX1 protein] | PMID:23022510 PMID:27028516 PMID:29663635 PMID:29940330 PMID:31585129 | | ||||||||||||||||||||||
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