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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:28428
Term: beta-hexachlorocyclohexane
Definition: The beta-isomer of hexachlorocyclohexane.
Chemical ID: MESH:C023888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2increases activityISOERBB2 (Homo sapiens)6480464CTDbeta-hexachlorocyclohexane results in increased activity of ERBB2 proteinPMID:11222871 PMID:9443065
Erbb2increases expressionISOErbb2 (Mus musculus)6480464CTDbeta-hexachlorocyclohexane results in increased expression of ERBB2 mRNAPMID:17640349
Erbb2increases expressionISOERBB2 (Homo sapiens)6480464CTDbeta-hexachlorocyclohexane results in increased expression of ERBB2 proteinPMID:12948864
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]PMID:12439862
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