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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:28200
Term: 2-chloroethanol
Definition: A chloroethanol carrying a chloro substituent at position 2.
Chemical ID: MESH:D005023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDEthylene Chlorohydrin results in increased expression of CYP2E1 mRNA; Ethylene Chlorohydrin results in increased expression of CYP2E1 proteinPMID:31585129
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDallyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; Ascorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; mithramycin A inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 mRNA]; SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of CYP2E1 protein]PMID:31585129
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