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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606841
Species: Homo sapiens
RGD Object: Gene
Symbol: NKX2-5
Name: NK2 homeobox 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NKX2-5affects expressionISONkx2-5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NKX2-5 mRNAPMID:21570461
NKX2-5decreases expressionISONkx2-5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NKX2-5 mRNA; Tetrachlorodibenzodioxin results in decreased expression of NKX2-5 proteinPMID:20130022
NKX2-5decreases localizationISONkx2-5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased localization of NKX2-5 proteinPMID:26139165
NKX2-5increases expressionISONkx2-5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of NKX2-5 mRNAPMID:24058054
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