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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11075
Species: Mus musculus
RGD Object: Gene
Symbol: Pepd
Name: peptidase D
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pepdaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of PEPD mRNAPMID:18343893 PMID:21570461 PMID:26377647
Pepdincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PEPD mRNAPMID:15328365 PMID:27562557
Pepdmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PEPD mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PEPD mRNAPMID:16214954 PMID:17942748
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