GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd1 | affects expression | EXP | | 6480464 | CTD | Cocaine affects the expression of DRD1 protein | PMID:11602327 PMID:15049517 PMID:20435100 | Drd1 | affects response to substance | EXP | | 6480464 | CTD | DRD1 protein affects the susceptibility to Cocaine | PMID:2213551 | Drd1 | decreases expression | EXP | | 6480464 | CTD | Cocaine results in decreased expression of DRD1 protein | PMID:27129946 | Drd1 | multiple interactions | EXP | | 6480464 | CTD | [anhydroecgonine methyl ester co-treated with Cocaine] results in decreased expression of DRD1 protein; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein] | PMID:11421588 PMID:16674926 PMID:17161392 PMID:27129946 | Drd1 | affects expression | ISO | Drd1 (Mus musculus) | 6480464 | CTD | Cocaine affects the expression of DRD1 protein | PMID:35597300 | Drd1 | decreases response to substance | ISO | Drd1 (Mus musculus) | 6480464 | CTD | DRD1 gene mutant form results in decreased susceptibility to Cocaine | PMID:8001143 | Drd1 | increases expression | ISO | Drd1 (Mus musculus) | 6480464 | CTD | Cocaine deficiency results in increased expression of DRD1 mRNA | PMID:27126842 | Drd1 | increases response to substance | ISO | Drd1 (Mus musculus) | 6480464 | CTD | DRD1 results in increased susceptibility to Cocaine | PMID:20456009 | Drd1 | multiple interactions | ISO | Drd1 (Mus musculus) | 6480464 | CTD | Cocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] | PMID:15056714 PMID:20456009 | Drd1 | multiple interactions | ISO | DRD1 (Homo sapiens) | 6480464 | CTD | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]; Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] | PMID:20956312 | | ||||||||||||||||||||||
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