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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Flt1
Name: Fms related receptor tyrosine kinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Flt1decreases expressionISOFLT1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of FLT1 mRNA; resveratrol results in decreased expression of FLT1 proteinPMID:17992120 PMID:26933402
Flt1decreases secretionISOFLT1 (Homo sapiens)6480464CTDresveratrol results in decreased secretion of FLT1 proteinPMID:22197494 PMID:26933402
Flt1multiple interactionsISOFLT1 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased expression of FLT1 mRNA]; resveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased secretion of FLT1 protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of FLT1 protein]PMID:22197494 PMID:26933402
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