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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62249
Species: Mus musculus
RGD Object: Gene
Symbol: Nt5e
Name: 5' nucleotidase, ecto
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nt5edecreases activityISONt5e (Rattus norvegicus)6480464CTDCaffeine results in decreased activity of NT5E proteinPMID:28465162
Nt5emultiple interactionsISONt5e (Rattus norvegicus)6480464CTDcaffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]PMID:28465162
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