GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HMOX1 | affects response to substance | EXP | | 6480464 | CTD | HMOX1 gene polymorphism affects the susceptibility to Arsenic | PMID:20708634 PMID:20796278 | HMOX1 | decreases expression | EXP | | 6480464 | CTD | Arsenic results in decreased expression of HMOX1 mRNA | PMID:36861143 | HMOX1 | decreases ubiquitination | EXP | | 6480464 | CTD | Arsenic results in decreased ubiquitination of HMOX1 protein | PMID:35821281 | HMOX1 | increases acetylation | EXP | | 6480464 | CTD | Arsenic results in increased acetylation of HMOX1 protein | PMID:35821281 | HMOX1 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of HMOX1 mRNA; Arsenic results in increased expression of HMOX1 protein | PMID:19945496 PMID:20478284 PMID:23794209 PMID:29247444 PMID:29248574 PMID:35821281 PMID:36720308 | HMOX1 | multiple interactions | EXP | | 6480464 | CTD | [Arsenic co-treated with Selenium] results in increased expression of HMOX1 mRNA; [Arsenic co-treated with Selenium] results in increased expression of HMOX1 protein; [Arsenic results in decreased activity of USP7 protein] which results in decreased ubiquitination of HMOX1 protein; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of HMOX1 mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein; [Water Pollutants, Chemical co-treated with Arsenic] results in increased expression of HMOX1 mRNA; Arsenic inhibits the reaction [[USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic inhibits the reaction [Arsenic results in decreased expression of HMOX1 mRNA]; Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]; Arsenic inhibits the reaction [USP7 protein results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [[USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]]; ATG7 protein affects the reaction [[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Arsenic results in increased expression of H2AX protein]; NFE2L2 protein affects the reaction [[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]; P5091 inhibits the reaction [Arsenic results in increased expression of HMOX1 protein]; SQSTM1 protein affects the reaction [[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]; USP7 protein affects the reaction [Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]]; USP7 protein affects the reaction [Arsenic results in increased expression of HMOX1 protein]; USP7 protein mutant form inhibits the reaction [Arsenic results in decreased ubiquitination of HMOX1 protein] | PMID:20478284 PMID:26472158 PMID:32525701 PMID:33434570 PMID:35809665 PMID:35821281 PMID:36861143 | HMOX1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of HMOX1 mRNA; Arsenic results in increased expression of HMOX1 protein | PMID:15337587 PMID:23000044 PMID:35821281 | HMOX1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein; NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of HMOX1 mRNA]; P5091 inhibits the reaction [Arsenic results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]] | PMID:23000044 PMID:31238026 PMID:33049506 PMID:33213951 PMID:35821281 | HMOX1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of HMOX1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]; Zinc deficiency inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA] | PMID:31542844 PMID:35598369 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |