GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1a | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Mitomycin results in increased expression of CDKN1A mRNA | PMID:25270620 | Cdkn1a | increases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased expression of CDKN1A mRNA; Mitomycin results in increased expression of CDKN1A protein | PMID:18647660 PMID:24211769 PMID:34624459 | Cdkn1a | multiple interactions | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | [Mitomycin co-treated with Resveratrol] results in increased expression of CDKN1A; [Mitomycin results in increased stability of TP53 protein] which results in increased expression of CDKN1A mRNA; AKT1 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]; baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]]; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; GSK3B protein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; Mitomycin promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; perifosine inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein] | PMID:15905168 PMID:18647660 PMID:20536192 PMID:25275039 PMID:34624459 | | ||||||||||||||||||||||
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