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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735684
Species: Mus musculus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31, member 1
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1decreases activityEXP 6480464CTDCopper Sulfate results in decreased activity of SLC31A1 proteinPMID:20631178
Slc31a1multiple interactionsEXP 6480464CTD[Copper Sulfate results in decreased activity of SLC31A1 protein] which results in decreased uptake of Cisplatin; Copper Sulfate inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Copper Sulfate inhibits the reaction [SLC31A1 gene mutant form inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]PMID:20631178 PMID:22842628
Slc31a1decreases expressionISOSLC31A1 (Homo sapiens)6480464CTD[Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA; Copper Sulfate results in decreased expression of SLC31A1 mRNAPMID:19549813 PMID:22172574 PMID:22914438
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTDCopper Sulfate inhibits the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]; Copper Sulfate inhibits the reaction [SLC31A1 protein results in increased import of Cisplatin]; Copper Sulfate inhibits the reaction [SP1 protein binds to SLC31A1 promoter]PMID:22172574 PMID:24132751
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