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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDCopper Sulfate results in increased expression of HMOX1 mRNA; Copper Sulfate results in increased expression of HMOX1 proteinPMID:16283523 PMID:17244614 PMID:19549813 PMID:19683516 PMID:33839236
HMOX1multiple interactionsEXP 6480464CTD[Buthionine Sulfoximine co-treated with Ascorbic Acid] promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; [ethyl maltol results in increased susceptibility to [Copper Sulfate results in increased abundance of Copper]] which results in increased expression of HMOX1 mRNA; [ethyl maltol results in increased susceptibility to [Copper Sulfate results in increased abundance of Copper]] which results in increased expression of HMOX1 protein; Buthionine Sulfoximine promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Dehydroascorbic Acid promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]PMID:19683516 PMID:33271249
HMOX1decreases expressionISOHmox1 (Mus musculus)6480464CTDCopper Sulfate results in decreased expression of HMOX1 mRNAPMID:18579281
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDCopper Sulfate results in increased expression of HMOX1 proteinPMID:25749341 PMID:37353053
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein]; APOE protein inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein]PMID:25749341 PMID:37353053
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