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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733249
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC28A1
Name: solute carrier family 28 member 1
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC28A1increases response to substanceEXP 6480464CTDSLC28A1 protein results in increased susceptibility to AzacitidinePMID:19139132
SLC28A1increases uptakeEXP 6480464CTDSLC28A1 protein results in increased uptake of AzacitidinePMID:19139132
SLC28A1multiple interactionsEXP 6480464CTD[SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein; Sodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine]PMID:19139132
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