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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2324
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2b
Name: cyclin-dependent kinase inhibitor 2B
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2baffects response to substanceISOCDKN2B (Homo sapiens)6480464CTDCDKN2B promoter modified form affects the susceptibility to AzacitidinePMID:17611569
Cdkn2bdecreases methylationISOCDKN2B (Homo sapiens)6480464CTDAzacitidine results in decreased methylation of CDKN2B promoterPMID:19194470
Cdkn2bmultiple interactionsISOCDKN2B (Homo sapiens)6480464CTD[metacept-1 co-treated with Azacitidine] results in increased expression of CDKN2BPMID:19148494
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