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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314001
Species: Homo sapiens
RGD Object: Gene
Symbol: PINK1
Name: PTEN induced kinase 1
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PINK1increases expressionISOPink1 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of PINK1 proteinPMID:37692514
PINK1multiple interactionsISOPink1 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]; Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]PMID:37692514
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