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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTDMelatonin results in decreased expression of HMOX1 mRNAPMID:21442002
Hmox1increases expressionEXP 6480464CTDMelatonin results in increased expression of HMOX1 proteinPMID:20433640
Hmox1multiple interactionsEXP 6480464CTDMelatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 PMID:20197452 PMID:20433640 PMID:21986892 PMID:30372842 PMID:35598369
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDMelatonin results in increased expression of HMOX1 proteinPMID:25288107
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of HMOX1 mRNA]]PMID:25288107 PMID:27871981 PMID:34146326 PMID:37598416
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]PMID:10942521
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