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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFdecreases expressionEXP 6480464CTDTrichloroethylene results in decreased expression of TNF proteinPMID:29477354
TNFdecreases expressionISOTnf (Mus musculus)6480464CTDTrichloroethylene results in decreased expression of TNF mRNA; Trichloroethylene results in decreased expression of TNF proteinPMID:18958647 PMID:22407948
TNFincreases expressionISOTnf (Mus musculus)6480464CTDTrichloroethylene metabolite results in increased expression of TNF mRNA; Trichloroethylene results in increased expression of TNF mRNA; Trichloroethylene results in increased expression of TNF proteinPMID:20709644 PMID:23037997 PMID:26095957 PMID:29669109 PMID:32763311 PMID:33930529
TNFincreases expressionISOTnf (Rattus norvegicus)6480464CTDTrichloroethylene results in increased expression of TNF proteinPMID:18006135
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein; N-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide inhibits the reaction [Trichloroethylene results in increased expression of TNF protein]; N-(benzyloxycarbonyl)-phenylalanyl-tyrosinal inhibits the reaction [Trichloroethylene results in increased expression of TNF protein]; sulforaphane inhibits the reaction [Trichloroethylene results in increased expression of TNF mRNA]PMID:26095957 PMID:32763311 PMID:33007382 PMID:33930529
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