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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityEXP 6480464CTDLipopolysaccharides results in decreased activity of CYP1A2 proteinPMID:15542068 PMID:15710352
Cyp1a2multiple interactionsEXP 6480464CTDClenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]]PMID:15542068 PMID:15710352
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDLipopolysaccharides inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]PMID:22466549
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