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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313253
Species: Mus musculus
RGD Object: Gene
Symbol: Irak4
Name: interleukin-1 receptor-associated kinase 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irak4increases degradationEXP 6480464CTDLipopolysaccharides results in increased degradation of IRAK4 proteinPMID:22849695
Irak4increases phosphorylationEXP 6480464CTDLipopolysaccharides results in increased phosphorylation of IRAK4 proteinPMID:25294874
Irak4multiple interactionsEXP 6480464CTDginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK4 protein]; iberin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK4 protein]PMID:22849695 PMID:25294874
Irak4increases expressionISOIRAK4 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IRAK4 proteinPMID:28964808
Irak4multiple interactionsISOIrak4 (Rattus norvegicus)6480464CTD[Lipopolysaccharides co-treated with Titanium] results in decreased expression of IRAK4 mRNAPMID:21308757
Irak4multiple interactionsISOIRAK4 (Homo sapiens)6480464CTD[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 protein; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 mRNA]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 protein]PMID:28964808
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