Gene: Irak4 (interleukin-1 receptor-associated kinase 4) Rattus norvegicus
Symbol: Irak4
Name: interleukin-1 receptor-associated kinase 4
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway; JNK cascade; positive regulation of smooth muscle cell proliferation; PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; ASSOCIATED WITH Brain Ischemia; Sepsis; Bacterial Infections and Mycoses (ortholog); FOUND IN extracellular space; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC300177
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.07135,803,723 - 135,831,006+NCBI
Rat Cytogenetic Map7q35 NCBI
RGSC Genome Assembly v5.07135,461,296 - 135,487,468+NCBI
RGSC Genome Assembly v3.47133,055,185 - 133,081,614+NCBI
Rat Celera Assembly7122,072,276 - 122,098,055+NCBI
Genome Assembly 3.17133,131,009 - 133,157,870+NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Irak4
Entrez Gene
Ensembl Gene
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1305303
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2015-11-09
Status: ACTIVE