Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1affects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of HMOX1 mRNA; Hydrogen Peroxide affects the expression of HMOX1 proteinPMID:32980322 PMID:36880193
HMOX1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of HMOX1 mRNA; Hydrogen Peroxide results in decreased expression of HMOX1 proteinPMID:31521693 PMID:36058301 PMID:36114797
HMOX1increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of HMOX1; Hydrogen Peroxide results in increased expression of HMOX1 mRNA; Hydrogen Peroxide results in increased expression of HMOX1 proteinPMID:10218639 PMID:12393473 PMID:12414654 PMID:16259763 PMID:16631525 PMID:18687144 PMID:21242307 PMID:21366594 PMID:23410634 PMID:27725188 PMID:28285367 PMID:29486183 PMID:30309986 PMID:33212048 PMID:33248029 PMID:34077701 PMID:9337616 PMID:9747510
HMOX1multiple interactionsEXP 6480464CTD1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; [butein results in increased expression of HMOX1 protein] inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]; [butein results in increased expression of HMOX1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [cobaltiprotoporphyrin results in increased activity of HMOX1 protein] inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]; [cobaltiprotoporphyrin results in increased activity of HMOX1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; [Hydrogen Peroxide co-treated with Butylated Hydroxyanisole] results in increased expression of HMOX1 mRNA; [Hydrogen Peroxide co-treated with loliolide] results in increased expression of HMOX1 mRNA; [Lycopene co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] inhibits the reaction [3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; [tin protoporphyrin IX results in decreased expression of and results in decreased activity of HMOX1 protein] inhibits the reaction [butein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; CDKN1A protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; HMOX1 protein affects the reaction [PINK1 protein affects the susceptibility to Hydrogen Peroxide]; Hydrogen Peroxide promotes the reaction [TP53 protein binds to HMOX1 promoter]; Hydrogen Peroxide promotes the reaction [TP53 protein results in increased expression of HMOX1 mRNA]; Hydrogen Peroxide promotes the reaction [TP53 protein results in increased expression of HMOX1 protein]; IGF1 protein promotes the reaction [kurarinone inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]]; Kangen-karyu inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; kurarinone inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; PINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 mRNA]; swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; TGFB1 protein affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; TRAP1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; TRAP1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]PMID:16259763 PMID:19961840 PMID:21366594 PMID:21552291 PMID:23318726 PMID:27725188 PMID:28285367 PMID:28974442 PMID:29486183 PMID:30231594 PMID:31521693 PMID:32980322 PMID:33212048 PMID:34077701 PMID:36058301 PMID:36114797 PMID:36880193 PMID:9747510
HMOX1affects expressionISOHmox1 (Rattus norvegicus)6480464CTDHydrogen Peroxide affects the expression of HMOX1 proteinPMID:24437944
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in decreased expression of HMOX1 mRNA; Hydrogen Peroxide results in decreased expression of HMOX1 proteinPMID:30104959 PMID:36305173
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of HMOX mRNA; Hydrogen Peroxide results in increased expression of HMOX1 mRNA; Hydrogen Peroxide results in increased expression of HMOX1 proteinPMID:11181820 PMID:12646174 PMID:21690482 PMID:24740755 PMID:29950142 PMID:31194955 PMID:35123994 PMID:7538129
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased expression of HMOX1; Hydrogen Peroxide results in increased expression of HMOX1 mRNAPMID:16464909 PMID:19386027 PMID:19497421 PMID:32275923 PMID:34047419 PMID:7743507
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[Hydrogen Peroxide co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased phosphorylation of HMOX1 protein; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; BACH1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX mRNA]; Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; HMOX1 enhancer affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [manganese chloride results in increased abundance of Hydrogen Peroxide]; Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of HMOX1 mRNA]; Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of HMOX1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of HMOX1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; SOD2 mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]PMID:12646174 PMID:21552291 PMID:21963524 PMID:24740755 PMID:29950142 PMID:31194955 PMID:31494107 PMID:7538129
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[Hydrogen Peroxide co-treated with Ammonium Sulfate] promotes the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased expression of HMOX1]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; Antioxidants inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; PLK2 protein promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; SESN2 protein promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]PMID:15035594 PMID:16464909 PMID:24437944 PMID:27028516 PMID:30104959 PMID:32275923 PMID:34047419
Go Back to source page   Continue to Ontology report