GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | decreases expression | EXP | | 6480464 | CTD | Dinoprostone results in decreased expression of TNF protein | PMID:16303787 | TNF | increases abundance | EXP | | 6480464 | CTD | TNF protein results in increased abundance of Dinoprostone; TNF results in increased abundance of Dinoprostone | PMID:1515551 PMID:16492401 PMID:18054255 PMID:19616084 PMID:1993070 PMID:23257246 PMID:27793764 | TNF | increases secretion | EXP | | 6480464 | CTD | TNF protein results in increased secretion of Dinoprostone | PMID:16784723 PMID:21334316 PMID:32613688 | TNF | multiple interactions | EXP | | 6480464 | CTD | 1-carboxyheptylimidazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; [Triclosan co-treated with Cetylpyridinium] inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; pyrrolidine dithiocarbamic acid promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]]; sorbinil inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased metabolism of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone] | PMID:10614771 PMID:12743569 PMID:1515551 PMID:15379866 PMID:15642051 PMID:16253096 PMID:16784723 PMID:18952292 PMID:1993070 PMID:20388727 PMID:21334316 PMID:21913898 PMID:23257246 PMID:25866079 PMID:27793764 PMID:32613688 PMID:9298541 | TNF | decreases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Dinoprostone results in decreased expression of TNF protein | PMID:7536779 | TNF | increases abundance | ISO | Tnf (Mus musculus) | 6480464 | CTD | TNF protein results in increased abundance of Dinoprostone | PMID:15489888 PMID:9576062 | TNF | increases abundance | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | TNF protein results in increased abundance of Dinoprostone; TNF protein results in increased abundance of Dinoprostone metabolite | PMID:16754782 PMID:21745554 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF protein]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone] | PMID:10495789 PMID:11301049 PMID:14623498 PMID:15489888 PMID:17067557 PMID:25432964 PMID:9576062 | TNF | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [TNF protein results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone metabolite]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; TNF protein promotes the reaction [Benzo(a)pyrene results in increased abundance of Dinoprostone] | PMID:16754782 PMID:21745554 PMID:21803157 PMID:22039321 | | ||||||||||||||||||||||
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