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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737502
Species: Mus musculus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase, muscle
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PKM proteinPMID:35999755
Pkmincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PKM mRNAPMID:26063408
Pkmaffects expressionISOPkm (Rattus norvegicus)6480464CTDbisphenol A affects the expression of PKM mRNAPMID:32145629
Pkmaffects expressionISOPKM (Homo sapiens)6480464CTDbisphenol A affects the expression of PKM mRNAPMID:30903817
Pkmdecreases expressionISOPKM (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PKM proteinPMID:34186270
Pkmincreases expressionISOPkm (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of PKM mRNAPMID:12075121 PMID:25181051
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDbisphenol A results in increased expression of PKM mRNA; bisphenol A results in increased expression of PKM proteinPMID:19371625 PMID:33670352 PMID:37567409
Pkmmultiple interactionsISOPkm (Rattus norvegicus)6480464CTD[Fructose co-treated with bisphenol A] results in decreased expression of PKM proteinPMID:26930160
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PKM mRNAPMID:28628672
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