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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737502
Species: Mus musculus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase, muscle
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM proteinPMID:32917723 PMID:34481905
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein; AZD3965 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; HMGA2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; PKM protein affects the reaction [[Lactic Acid promotes the reaction [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of CCND1 protein]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNE1 protein]]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein]]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]PMID:34481905 PMID:36336208
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