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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735908
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna2multiple interactionsISOChrna2 (Rattus norvegicus)2303194RGDnicotine affects binding competes with [Epibatidine binds to Chrna2 protein] 
Chrna2multiple interactionsISOChrna2 (Rattus norvegicus)2303195RGDnicotine affects binding to Chrna2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina 
Chrna2affects response to substanceISOCHRNA2 (Homo sapiens)6480464CTDCHRNA2 gene mutant form affects the susceptibility to NicotinePMID:19383498
Chrna2multiple interactionsISOCHRNA2 (Homo sapiens)6480464CTDNicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]PMID:9454827
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