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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735524
Species: Mus musculus
RGD Object: Gene
Symbol: Hspb8
Name: heat shock protein 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspb8affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of HSPB8 mRNAPMID:21570461
Hspb8decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HSPB8 mRNAPMID:19770486 PMID:21889950 PMID:33956508
Hspb8affects expressionISOHspb8 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of HSPB8 mRNAPMID:32109520 PMID:34747641
Hspb8decreases expressionISOHSPB8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of HSPB8 mRNAPMID:29704546
Hspb8increases expressionISOHSPB8 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of HSPB8 mRNAPMID:19619570 PMID:20106945 PMID:21296121 PMID:21632981 PMID:22071320
Hspb8increases expressionISOHspb8 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of HSPB8 mRNAPMID:33387578
Hspb8multiple interactionsISOHSPB8 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNA; [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of HSPB8 mRNA; [Tetrachlorodibenzodioxin promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] which results in decreased expression of HSPB8 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSPB8 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to HSPB8 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to HSPB8 promoter]; Tetrachlorodibenzodioxin promotes the reaction [NRIP1 protein binds to HSPB8 promoter]PMID:19619570 PMID:22071320 PMID:29704546
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