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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735524
Species: Mus musculus
RGD Object: Gene
Symbol: Hspb8
Name: heat shock protein 8
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspb8increases expressionISOHSPB8 (Homo sapiens)6480464CTDEstradiol results in increased expression of HSPB8 mRNAPMID:19619570 PMID:20106945 PMID:21185374 PMID:22071320 PMID:23524099 PMID:24758408 PMID:27514991 PMID:31614463
Hspb8multiple interactionsISOHSPB8 (Homo sapiens)6480464CTD[Estradiol co-treated with EGF protein] results in increased expression of HSPB8 mRNA; [Estradiol co-treated with Progesterone] results in increased expression of HSPB8 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNA; [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] which results in decreased expression of HSPB8 mRNA; AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]; AHR protein inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]; Estradiol promotes the reaction [AHR protein binds to HSPB8 promoter]; Estradiol promotes the reaction [ARNT protein binds to HSPB8 promoter]; Estradiol promotes the reaction [ESR1 protein binds to HSPB8 promoter]; Estradiol promotes the reaction [ESR2 protein affects the expression of HSPB8 mRNA]; Estradiol promotes the reaction [HSF protein binds to HSPB8 promoter]; Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]PMID:19619570 PMID:20404318 PMID:20660070 PMID:21185374 PMID:22071320 PMID:24758408 PMID:31614463
Hspb8multiple interactionsISOHspb8 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of HSPB8 mRNAPMID:26496021
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