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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:6375
Term: lansoprazole
Definition: A sulfoxide that has formula C16H14F3N3O2S.
Chemical ID: MESH:D064747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDLansoprazole results in increased expression of NFE2L2 mRNAPMID:28412091
NFE2L2increases phosphorylationISONfe2l2 (Rattus norvegicus)6480464CTDLansoprazole results in increased phosphorylation of NFE2L2 proteinPMID:19628634
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDLansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]PMID:19628634 PMID:28412091
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