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GENE - TERM ANNOTATION REPORT

RGD ID: 734345
Species: Homo sapiens
RGD Object: Gene
Symbol: PCSK1
Name: proprotein convertase subtilisin/kexin type 1
Acc ID: GO:0030141
Term: secretory granule
Definition: A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
Definition Source(s): GOC:mah, ISBN:0198506732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCSK1 ISOPcsk1 (Rattus norvegicus)9068941RGD PMID:10806118 REF_RGD_ID:1625123
PCSK1located_inIEAUniProtKB:P28840 or UniProtKB:P63239 or ensembl:ENSMUSP00000022075 or ensembl:ENSRNOP00000015185150520179Ensembl GO_REF:0000107
PCSK1is_active_inISOPcsk1 (Mus musculus)9068941MGI PMID:12136131

PMID:12136131
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