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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734055
Species: Mus musculus
RGD Object: Gene
Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncf1affects localizationEXP 6480464CTDHomocysteine affects the localization of NCF1 proteinPMID:20036696
Ncf1multiple interactionsEXP 6480464CTDFilipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]PMID:20036696
Ncf1affects localizationISONCF1 (Homo sapiens)6480464CTDHomocysteine affects the localization of NCF1 proteinPMID:16845898
Ncf1increases phosphorylationISONCF1 (Homo sapiens)6480464CTDHomocysteine results in increased phosphorylation of NCF1 proteinPMID:16845898
Ncf1multiple interactionsISONCF1 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein]; Homocysteine promotes the reaction [NCF1 protein results in increased abundance of Reactive Oxygen Species]; Homocysteine results in increased localization of and results in increased activity of NCF1 proteinPMID:16845898 PMID:17586618
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