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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734049
Species: Homo sapiens
RGD Object: Gene
Symbol: COL1A1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL1A1decreases expressionEXP 6480464CTDDactinomycin results in decreased expression of COL1A1 mRNAPMID:11216681
COL1A1multiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]PMID:18253093
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