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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733442
Species: Mus musculus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EIF4EBP1 mRNAPMID:21570461
Eif4ebp1affects expressionISOEif4ebp1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of EIF4EBP1 mRNAPMID:34747641
Eif4ebp1increases expressionISOEif4ebp1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of EIF4EBP1 mRNAPMID:33387578
Eif4ebp1multiple interactionsISOEif4ebp1 (Rattus norvegicus)6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of EIF4EBP1 protein]; IGF1 protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of and results in decreased activity of EIF4EBP1 protein]; Tetrachlorodibenzodioxin results in decreased phosphorylation of and results in decreased activity of EIF4EBP1 proteinPMID:23639626
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