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GENE - TERM ANNOTATION REPORT

RGD ID: 732968
Species: Homo sapiens
RGD Object: Gene
Symbol: XRCC1
Name: X-ray repair cross complementing 1
Acc ID: DOID:5082
Term: liver cirrhosis
Definition: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Definition Source(s): MESH:D008103
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XRCC1susceptibilityIAGP 14985244RGDassociated with Human Viral Hepatitis;DNA:missense mutation:cds:p.R399Q (rs25487) (human) 
XRCC1susceptibilityIAGP 15036794RGDassociated with hepatitis B;DNA:missense mutation, haplotype:cds:p.R399Q (human) 
XRCC1susceptibilityIAGP 15036797RGDassociated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R194W (human) 
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