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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:65345
Term: PX-866
Definition: An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.
Chemical ID: MESH:C496788
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationEXP 6480464CTDPX-866 results in decreased phosphorylation of AKT1 proteinPMID:28634229
AKT1multiple interactionsEXP 6480464CTDPX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]PMID:28634229
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDPX-866 results in decreased phosphorylation of AKT1 proteinPMID:25805502
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