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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732800
Species: Homo sapiens
RGD Object: Gene
Symbol: CAPN2
Name: calpain 2
Acc ID: CHEBI:5759
Term: Honokiol
Definition: A biphenyl that has formula C18H18O2.
Chemical ID: MESH:C005499
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CAPN2increases expressionEXP 6480464CTDhonokiol results in increased expression of CAPN2 proteinPMID:34973135
CAPN2multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [honokiol results in increased expression of CAPN2 protein]; CAPN2 protein promotes the reaction [honokiol results in decreased expression of and results in decreased activity of CEBPB protein]; CAPN2 protein promotes the reaction [honokiol results in decreased expression of HDAC3 protein]; CAPN2 protein promotes the reaction [honokiol results in decreased expression of RELA protein]; CEBPB protein inhibits the reaction [honokiol results in increased expression of CAPN2 protein]; RELA protein inhibits the reaction [honokiol results in increased expression of CAPN2 protein]PMID:34973135
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