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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDHomocysteine results in increased phosphorylation of MAPK1 proteinPMID:19850060
Mapk1multiple interactionsEXP 6480464CTD6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]PMID:19850060
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDHomocysteine results in increased phosphorylation of MAPK1 proteinPMID:16251475 PMID:25888188
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]PMID:16251475 PMID:25888188
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