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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732095
Species: Mus musculus
RGD Object: Gene
Symbol: Pcna
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcnamultiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [IL2 protein results in increased expression of PCNA mRNA]PMID:11355896
Pcnadecreases expressionISOPCNA (Homo sapiens)6480464CTDSirolimus results in decreased expression of PCNA proteinPMID:9151781
Pcnamultiple interactionsISOPCNA (Homo sapiens)6480464CTD[fulvestrant co-treated with Sirolimus] results in decreased expression of PCNA mRNAPMID:19016759
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