GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a13 | increases expression | ISO | Cyp3a9 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in increased expression of CYP3A9 mRNA | PMID:20888898 | Cyp3a13 | increases oxidation | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased oxidation of Lithocholic Acid | PMID:31102695 | Cyp3a13 | multiple interactions | ISO | CYP3A7 (Homo sapiens) | 6480464 | CTD | [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA | PMID:14570758 | Cyp3a13 | multiple interactions | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | [CYP3A5 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; CYP3A5 gene polymorphism affects the reaction [CYP3A5 gene results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; plastochromanol 8 inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid] | PMID:31102695 | | ||||||||||||||||||||||
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