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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731555
Species: Mus musculus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckmultiple interactionsEXP 6480464CTD[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein]; [Dietary Fats co-treated with Streptozocin] results in decreased activity of GCK protein; [Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in decreased expression of GCK protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of GCK mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of GCK protein; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA]PMID:25446853 PMID:26522834 PMID:27769711 PMID:29127188 PMID:33359794 PMID:33484791
Gckdecreases expressionISOGck (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of GCK mRNAPMID:27038876
Gckmultiple interactionsISOGck (Rattus norvegicus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA; Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of GCK mRNA]; repaglinide analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA]PMID:27038876 PMID:35702883
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