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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731555
Species: Mus musculus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:76451
Term: alloxan
Definition: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical ID: MESH:D000496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckdecreases expressionEXP 6480464CTDAlloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK proteinPMID:12137914 PMID:26827782
Gckmultiple interactionsEXP 6480464CTDGlucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]PMID:12137914 PMID:26827782
Gckdecreases expressionISOGck (Rattus norvegicus)6480464CTDAlloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK proteinPMID:33359794
Gckmultiple interactionsISOGck (Rattus norvegicus)6480464CTDginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK protein]PMID:33359794
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