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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731474
Species: Mus musculus
RGD Object: Gene
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs1decreases expressionISOHmgcs1 (Rattus norvegicus)6480464CTDFlutamide results in decreased expression of HMGCS1 mRNAPMID:24136188
Hmgcs1increases expressionISOHmgcs1 (Rattus norvegicus)6480464CTDFlutamide results in increased expression of HMGCS1 mRNA; Flutamide results in increased expression of HMGCS1 proteinPMID:17311803 PMID:19299419 PMID:21525395
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