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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731474
Species: Mus musculus
RGD Object: Gene
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of HMGCS1 mRNAPMID:30508572
Hmgcs1increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of HMGCS1 mRNAPMID:17681415 PMID:19429403 PMID:25092180 PMID:30657992
Hmgcs1multiple interactionsEXP 6480464CTDDietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of HMGCS1 mRNA]PMID:23626681
Hmgcs1increases expressionISOHmgcs1 (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in increased expression of HMGCS1 mRNAPMID:37236338
Hmgcs1increases expressionISOHMGCS1 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of HMGCS1 mRNAPMID:23978341 PMID:35337807
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