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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731474
Species: Mus musculus
RGD Object: Gene
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs1increases expressionEXP 6480464CTDbisphenol A results in increased expression of HMGCS1 mRNAPMID:25270620
Hmgcs1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of HMGCS1 mRNAPMID:28433925
Hmgcs1affects expressionISOHmgcs1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of HMGCS1 mRNAPMID:30903817
Hmgcs1affects expressionISOHMGCS1 (Homo sapiens)6480464CTDbisphenol A affects the expression of HMGCS1 mRNAPMID:30903817
Hmgcs1decreases expressionISOHmgcs1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HMGCS1 mRNAPMID:15901920 PMID:26982218 PMID:32145629
Hmgcs1decreases expressionISOHMGCS1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of HMGCS1 mRNA; bisphenol A results in decreased expression of HMGCS1 proteinPMID:27979917 PMID:37567409
Hmgcs1increases expressionISOHmgcs1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HMGCS1 mRNAPMID:25181051 PMID:29552716
Hmgcs1increases expressionISOHMGCS1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of HMGCS1 proteinPMID:34186270
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